Neuropsychological testing profiles in HIV with HAND compared to MCI, AD and
 
   Lead Investigator:    Benedetta Milanini
   Institution      :    UCSF
   E-Mail           :    Benedetta.Milanini@ucsf.edu
   Proposal ID      :    579



   Proposal Description:
   1)With advancing age, HIV-infected individuals, already at risk for               HIV-associated neurocognitive disorders (HAND), are at increased risk of          developing other neurodegenerative disorders, such as Alzheimer???s disease       (AD). Differentiating HAND from AD in older HIV-infected subjects has become a    major clinical challenge. In this study we aim to compare  the                    neuropsychological testing performance of HIV-infected individuals aged 60 and    older, with the performance of age and gender-matched HIV-uninfected subjects     who had a clinical consensus diagnosis of AD and Mild Cognitive                   Impairment(MCI), and to healthy older individuals. The findings of this study     may help to clarify the relationship between HIV and aging on the brain and to    design interventions aimed to better manage HAND on people living and aging       with HIV.                                                                                                                                                           2)The objective of this study is to distinguish the cognitive profile of older    people with HIV from that one of patients with a diagnosis of AD or MCI. Our      secondary goal is to test the hypothesis that older HIV-infected subjects are     at greater risk to develop AD, considered the presence of two different risk      factors for cognitive impairment among these people: HIV status and aging.